Grey's Anatomy has become synonymous with heartbreak and emotional moments over the years. The show has had its fair share of heartbreaking scenes that have left viewers in tears. Here are the top 10 most heartbreaking moments from the popular medical drama.

1. Denny Duquette's death: One of the most devastating moments in Grey's Anatomy history was Denny's untimely death. His passing not only broke the hearts of the characters but also fans around the world.

2. George O'Malley's death: George's death came as a shock to viewers, as he heroically saved a woman from a bus accident but ended up being unrecognizable to his colleagues. This moment left fans sobbing and mourning the loss of a beloved character.

3. Lexie Grey's death: Lexie's death was another heartbreaking moment that had fans reaching for the tissues. Her love story with Mark Sloan and her untimely demise left viewers devastated.

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Mark Sloan's death: Mark's death was especially heartbreaking because it came shortly after Lexie's. Fans mourned the loss of their favorite "McSteamy" and his incredible bond with his best friend, Derek Shepherd.

5. Meredith's near-drowning: In a shocking twist, Meredith nearly drowned while trying to save patients in a ferry accident. The moment was emotionally charged and left audiences fearing for her life.

6. Cristina Yang leaving: When Cristina decided to leave Grey Sloan Memorial Hospital, fans were devastated.

Her departure marked the end of an era and left a void that could never be filled.

7. Derek Shepherd's death: One of the most iconic characters in Grey's Anatomy, Derek's death shook fans to their core. McDreamy's tragic end was a gut-wrenching moment that had fans in disbelief.

8. April and Jackson's daughter's death: The loss of April and Jackson's baby was a heartbreaking storyline that explored the pain and grief of losing a child. It was a poignant and emotional moment for both the characters and viewers.

9. Richard Webber's near-death experience: Richard's near-death experience after a surgery gone wrong was a highly emotional and heartbreaking moment. Fans were on the edge of their seats, praying for his survival.

10. Alex Karev's departure: Alex's sudden exit from the show left fans shocked and heartbroken. After years of character development and growth, his departure felt abrupt and left viewers longing for closure.

Grey's Anatomy has never been afraid to tug at the heartstrings, and these top 10 heartbreaking moments are a testament to the emotional power of the show.

Fans have come to expect heartbreak from Grey's, and these scenes are just a few examples of the tear-inducing moments that have made the show a staple in popular culture.