Grey's Anatomy has become synonymous with heartbreak and emotional moments over the years. The show has had its fair share of heartbreaking scenes that have left viewers in tears. Here are the top 10 most heartbreaking moments from the popular medical drama.

1. Denny Duquette's death: One of the most devastating moments in Grey's Anatomy history was Denny's untimely death. His passing not only broke the hearts of the characters but also fans around the world.

2. George O'Malley's death: George's death came as a shock to viewers, as he heroically saved a woman from a bus accident but ended up being unrecognizable to his colleagues. This moment left fans sobbing and mourning the loss of a beloved character.

3. Lexie Grey's death: Lexie's death was another heartbreaking moment that had fans reaching for the tissues. Her love story with Mark Sloan and her untimely demise left viewers devastated.

4. Mark Sloan's death: Mark's death was especially heartbreaking because it came shortly after Lexie's. Fans mourned the loss of their favorite "McSteamy" and his incredible bond with his best friend, Derek Shepherd.

5. Meredith's near-drowning: In a shocking twist, Meredith nearly drowned while trying to save patients in a ferry accident. The moment was emotionally charged and left audiences fearing for her life.

6. Cristina Yang leaving: When Cristina decided to leave Grey Sloan Memorial Hospital, fans were devastated. Her departure marked the end of an era and left a void that could never be filled.

7. Derek Shepherd's death: One of the most iconic characters in Grey's Anatomy, Derek's death shook fans to their core. McDreamy's tragic end was a gut-wrenching moment that had fans in disbelief.

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