Grey's Anatomy is a popular medical drama series that has managed to captivate audiences for more than a decade. Throughout its numerous seasons, the show has seen the unfortunate demise of several beloved characters, leaving viewers with a heavy heart. This article presents a list of the top 10 saddest deaths on Grey's Anatomy.

Leading the list is the death of George O'Malley, played by T.R. Knight. His demise was met with shock and sadness as George was a fan-favorite character. Other notable deaths include the likes of Derek Shepherd, Lexie Grey, and Mark Sloan, whose deaths caused major emotional upheaval among fans.

The article also mentions the heartbreaking loss of Dr. Miranda Bailey's patient, Denny Duquette. This particular death stood out due to the connection and bond that had formed between Denny and Dr. Bailey. Another emotional death was that of Dr. Mark Sloan, known as "McSteamy" to fans. His character's death came as a result of a plane crash, leaving viewers devastated.

In addition to these deaths, other characters such as Dr. Lexie Grey, Dr. April Kepner's son, and Dr. Mark Sloan's brother were also mentioned in the article. Each of their deaths invoked a sense of sorrow and despair among fans of the show.

Overall, the article focuses on the top 10 saddest character deaths in Grey's Anatomy, highlighting the emotional impact these deaths had on both the characters within the show and its dedicated fan base.