Grey's Anatomy is known for delivering emotional rollercoasters to its viewers, and this article highlights the top 10 saddest moments in the show's history. Whether it's devastating losses or heart-wrenching situations, the show has never failed to bring tears to its audience's eyes.

One of the most heartrending moments on the list is the death of George O'Malley. Viewers were left devastated when George, played by T.R. Knight, sacrificed his own life to save a stranger.

The scene was powerful and emotionally charged, leaving fans mourning the loss of a beloved character.

Another heart-wrenching moment was the death of Derek Shepherd, also known as McDreamy. Patrick Dempsey's character was involved in a tragic car accident, leaving viewers shocked and heartbroken. This moment marked the end of an era and brought tears to countless fans' eyes.

Other moments on the list include the plane crash that claimed the lives of several characters, the heartbreaking loss of Mark Sloan, and the emotional turmoil faced by Cristina Yang throughout her time on the show.

Grey's Anatomy has been known for its ability to tackle difficult and emotional storylines, and these top 10 saddest moments serve as a reminder of the show's emotional depth. Through its character-driven narratives and tragic events, the show has captivated audiences and kept them on the edge of their seats for years.

In the end, Grey's Anatomy continues to break our hearts and make us reach for the tissues. The show's ability to evoke such strong emotions is a testament to its storytelling and the talented actors who bring these moments to life.