Katherine Heigl's departure from Grey's Anatomy as Izzie Stevens was influenced by conflicts with showrunner Shonda Rhimes and the character's storyline developments. Heigl's strained relationship with Rhimes, caused by past comments and behavior, played a role in Izzie's exit. However, there is potential for Izzie to return in the future, providing closure for the character and Heigl. Rhimes has expressed openness to seeing Izzie again, and Heigl herself has shown interest in tying up her character's arc. This potential return would also signify the actor's growth and maturity.
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