Sara Ramirez, who played Callie Torres on Grey's Anatomy, left the show after season 12 in 2016. While many actors leave the series due to behind-the-scenes issues, that wasn't the case for Ramirez. She felt it was time to leave after being on the show for ten years. Ramirez left the door open to return someday, but that hasn't happened yet. Callie's departure seemed abrupt to some, but compared to other characters' fates on the show, it wasn't a bad ending.

Callie became one of the most important characters in Grey's Anatomy and the longest-running LGBT character in TV history. Since leaving the show, Ramirez has appeared in various television projects, including voiceover work for Disney children's programs and a role in the Sex And The City revival. While it's uncertain if Callie will return to Grey's Anatomy, there have been alumni revisiting the show in recent seasons, so the opportunity for Ramirez to come back as Callie is always a possibility.