31. Dr. Jackson Avery and Dr. Maggie Pierce were technically family
30. Dr. Izzie Stevens and Dr. George O'Malley are proof that sometimes the 'friends to lovers' trope goes wrong
29. Callie and George were outcasts who didn't fit together
28. Jackson Avery and Dr. Stephanie Edwards' relationship was just a plot device
27. April Kepner and Matthew Taylor had the sexual chemistry of oatmeal
26. Dr. Nathan Riggs never stood a chance with Meredith Grey
25. Rooting for Callie and Dr. Penny Blake was impossible
24. Amelia Shepherd and Owen Hunt were each other's sloppy seconds
23. Dr. Andrew Deluca and Meredith were magnetic, but never magical
22. Dr. Lexie Grey and Dr. Alex Karev just distracted each other
21. We'll never know what Andrew and Maggie could've been
20. Amelia Shepherd and Dr. Atticus Linclon are a well-balanced match
19. Cristina and Owen's story is memorable, but that doesn't mean the chemistry was electric
18. Jackson was always just a rebound relationship for Lexie
17. Catherine and Richard prove that passion has no age limit
16. Cristina Yang always deserved better than Preston Burke
15. Dr. Teddy Altman and Dr. Owen Hunt's marriage was inevitable from the start
14. Long-distance love turned into one of a lifetime for Maggie and Dr. Winston Ndugu
13. Alex found a second soulmate in Dr. Jo Wilson
12. Dr. Nick Marsh makes sense in Meredith's future
11. Dr. Kai Bartley brought some much-needed spice into Amelia's life
10. Beth and Jeremy make this list for an unforgettable reason
9. Izzie and Alex deserved their off-screen happily ever after
8. Dr. Miranda Bailey and Dr. Ben Warren are #MarriageGoals
7. Teddy's soulmate was a patient named Henry
6. Dr. Levi Schmitt and Dr. Nico Kim can't stay away from each other
5. In an alternate universe, Denny Duquette is Izzie's one true love
4. Not even death could keep Mark and Lexie apart
3. Dr. Callie Torres and Dr. Arizona Robbins couldn't stay apart for long
2. Meredith and Derek set the chemistry bar high
1. Jackson and April's chemistry is untouchable
