Grey's Anatomy, the long-running medical drama, has seen several actors leave the show for various reasons. Jesse Williams, who played Dr. Jackson Avery, left after his character's storyline reached a natural conclusion. Sara Ramirez, who portrayed Callie Torres, departed due to reaching their limit with the character. Justin Chambers' departure as Alex Karev was abrupt and surrounded by speculation. Chyler Leigh, Eric Dane, Isaiah Washington, T.R. Knight, Sandra Oh, Patrick Dempsey, and Katherine Heigl also left the show, each with their own reasons. Despite these departures, Grey's Anatomy remains popular and influential.
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