Patrick Dempsey's departure from Grey's Anatomy in 2015 was controversial, with former executive producer James D. Parriott revealing that there were "HR issues" and that Dempsey had a negative impact on the set. Dempsey himself admitted that the demanding schedule played a role in his decision to leave. He made a cameo appearance in 2021 as a healing process and to raise COVID awareness. Ellen Pompeo also expressed excitement about his return. The details are outlined in Lynette Rice's book, How to Save a Life: The Inside Story of Grey's Anatomy.
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