Shonda Rhimes, creator of Grey's Anatomy, rejected established television stars for key roles in order to stick to her original vision for the series. ABC executives wanted Rob Lowe and Kristin Chenoweth for the roles of Dr. Derek Shepherd and Dr. Miranda Bailey, but Rhimes insisted on casting lesser-known actors. This decision allowed the actors to fully embody their characters and build strong connections with the audience. The success of Grey's Anatomy demonstrates that a cast of unknown actors can be just as effective as familiar faces in creating a beloved and enduring television show.
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