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31 'Grey's Anatomy' couples ranked by their chemistry!
2024/03/05

"Grey's Anatomy" has aired over 400 episodes throughout 19 seasons of television. It's technically a procedural medical drama, but it's the romance that keeps viewers coming back for more generation after generation. 

We've ranked 31 of the show's most iconic couples by their chemistry. Our ranking was sometimes influenced by the couple's storyline but mostly determined by the amount of heat we felt through the TV screen, even when the characters were simply looking at one other from across a room. 

31. Dr. Jackson Avery and Dr. Maggie Pierce were technically family

30. Dr. Izzie Stevens and Dr. George O'Malley are proof that sometimes the 'friends to lovers' trope goes wrong

29. Callie and George were outcasts who didn't fit together

28. Jackson Avery and Dr. Stephanie Edwards' relationship was just a plot device 

27. April Kepner and Matthew Taylor had the sexual chemistry of oatmeal

26. Dr. Nathan Riggs never stood a chance with Meredith Grey

25. Rooting for Callie and Dr. Penny Blake was impossible

24. Amelia Shepherd and Owen Hunt were each other's sloppy seconds

23. Dr. Andrew Deluca and Meredith were magnetic, but never magical

22. Dr. Lexie Grey and Dr. Alex Karev just distracted each other

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