Grey's Anatomy, the long-running medical drama, has faced numerous cast departures over the years. Actors like Jesse Williams, Sara Ramirez, and Justin Chambers left the show for various reasons, including career aspirations and personal choices. These exits have led to impactful plot changes and emotional moments for viewers. Despite the changes, Grey's Anatomy remains a groundbreaking and influential series with a diverse cast and complex character relationships.

Lead actress Ellen Pompeo recently left as a series regular but continues to be involved as an executive producer.