Grey's Anatomy has featured many celebrity cameos over the years, some of whom appeared before they were famous. Demi Lovato played a misdiagnosed patient, Millie Bobby Brown played a young girl who saves her mother's life during an earthquake, Elisabeth Moss appeared as an overly-protective daughter, and Wilmer Valderrama had a recurring role as a musician who dies. Other notable cameos include Abigail Breslin, Mandy Moore, Keke Palmer, Christina Ricci, Leslie Odom Jr.

, Sarah Paulson, Tessa Thompson, and Jesse Plemons.